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AFR, EUR, SAS, EAS, and AMR represent the continental populations: African, European, South Asian, East Asian and Admixed Americans, respectively

Limited data exists about the impact beyond weight loss when GLP-1s are used in patients without a diagnosis of diabetes

Other research has reported that GLP-1 receptors are expressed throughout the gastrointestinal tract, promoting intestinal lining healing and regulating the gut microbiome, which may counteract inflammation and dysbiosis linked to colorectal cancer CRC

The blunted weight loss in mGIPR-Ab/P1-treated Glp1r Wnt1/ mice was associated with less reduction in food intake compared to Glp1r fl/fl controls (Fig