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The glutamate residue is linked through its side-chain carboxyl, giving a gamma-glutamyl bond rather than a standard alpha-peptide bond, which is why the molecule resists most intracellular peptidases and is cleaved chiefly by gamma-glutamyl transpeptidase at the cell surface
The molecule retains only the 176191 C-terminal fragment of hGH, which carries the lipolytic signal but lacks the sequence regions responsible for IGF-1 elevation and growth-promoting activity
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