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When food remains in the stomach for extended periods of time, patients may develop severe nausea, vomiting, dehydration, malnutrition, abdominal swelling, and painful digestive complications requiring hospitalization or emergency treatment

Furthermore, postmortem studies showed increased BDNF expression in hippocampus after antidepressant treatment [44]

The dual function of inhibiting MMP-2/9 activity and promoting angiogenesis was achieved by cleavage of TIMPs occupying upregulated MMP-2/9 and the simultaneous release of bFGF