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11,17,25 In addition, SGLT2i activate key regulatory pathways involving AMP-activated protein kinase (AMPK), sirtuin 1 (SIRT1), SIRT3, and peroxisome proliferator-activated receptor- coactivator 1 (PGC-1), leading to enhanced autophagic activity and suppression of inflammatory responses
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However, cellular effects and metabolic adaptations your body underwent during treatment may persist longer than the drug itself
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