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Melatonin's actions are not limited to sleep [PMID: 36970311] Laboratory literature summary: Melatonin's actions are not limited to sleep
Lilly said in an email that while both target metabolic disease, tirzepatide is a GIP/GLP-1 dual agonist injectable, whereas orforglipron is a selective, oral GLP-1 receptor agonist
The Wegovy pill nausea figure (46.6%) is high, but the discontinuation rate (7% on the medication vs 6% on placebo) is unusually close for a GLP-1 trial, which suggests most nausea was manageable
Most patients notice appetite suppression and early satiety within 2 to 4 weeks of beginning treatment
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