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Another possibility is that obesity could lower serum vitamin B12 levels through decreased dietary intake or absorption, increased catabolism, and sequestration in adipose tissue, or changes in the gut microbiota profiles which could affect the metabolism of vitamin B12

There were no significant differences in gender, age, smoking status, history of diabetes mellitus, and use of medications between the two groups at baseline

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The elements to consider in such a composite profiling, for a principal component analysis, could be for instance the following