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The appetite-suppressing effects begin within hours, and eating a heavy meal right before injection can amplify nausea as the slowed gastric emptying takes effect
These factors have led to the ADA/EASD recommendation that GLP-1 RAs be the preferred first injectable glucose-lowering agent for T2D (ahead of insulin therapy
Since this phase of the trial was successful, the next step is a longer clinical phase 2 trial
Oral semaglutide reduces HbA1c and body weight in patients with type 2 diabetes regardless of background glucose-lowering medication: PIONEER subgroup analyses
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