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And it appears endogenous GLP-1 does just that, it helps locally and temporarily to help suppress T-cell inflammation, the problem is that the half-life of endogenous GLP-1 is just a few minutes, so any systemic effects are somewhat muted

Both cytoplasmic and nuclear accumulations of the protein are neurotoxic in Drosophila models of TDP-43 proteinopathies

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