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For example, NAM can inhibit the activity of human sirtuin 1 (SIRT1) and PARPs in vitro 55,56
At the same time 32% of those studied experienced adverse events, including liver dysfunction and one case of anaphylaxis (Alzahrani et al., Cureus 2025, PMID 40013212)
For most healthy adults, oral glutathione at the recommended dose is considered safe for daily use
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