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GS-conjugates are actively transported out of cells by efflux transporters including MRP1 and P-glycoprotein belonging to the superfamily of ATP-binding cassette transporters 70,71,72
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Ann Palliat Med , 4 , 7077
The Ongoing Debate: Concerns About Pediatric GLP-1 Use Critics raise several significant concerns: Growth and Development: Impact during crucial developmental years Hormonal Effects: Potential interference with puberty and bone building Psychological Impact: Risk of trauma from the medicalization of body image Long-term Effects: Limited data on lifetime use starting in childhood Eating Disorders: Concerns from organizations like the Collaborative of Eating Disorders Organizations Some physicians have cried foul, arguing that the introduction of these medications during a period of significant growth and development could come with adverse health effects
