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Considering the control incubations: only carbon-1 of glucose gives rise to carbon dioxide, and the radioactivity in (lactate + pyruvate) is lower from [14C-1]glucose than the other positional isomers
The GCGR component is specifically hypothesised to contribute via cyclic AMP-mediated beta-oxidation pathways in hepatocytes, though this mechanistic attribution requires further controlled validation [VERIFY]
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TB-500, VIP, and KPV remain in the preclinical stage
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