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Carvalho M, Almeida IF
As of July 2026, neither the agency nor Novo Nordisk has publicly confirmed a PDUFA date for the CagriSema FDA review
As mentioned above, there are more than 100 Akt substrates mainly including GLUT4, FOXO1, GSK3, mTORC1, SREBP-1c, TSC1/2, PRAS40, ABHD15, PDE3B
However, inappropriate activation of inflammasomes, including NLRP3 and NLRX1, is closely related to multiple autoimmune diseases, such as SLE, RA, and other inflammatory diseases, which is well summarized and discussed in two recently published review articles (105, 106)
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