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However, the boxed warning regarding thyroid C-cell tumors observed in rodent studies remains relevant, and thorough patient screening is essential before initiating therapy

Our model is in agreement with the local S-palmitoylation described for substrates such as PSD-95 at dendritic spines 37 and calnexin at the ER 47 , but adds the Golgi as a compartment in which PMPs can be locally modified and retained