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Copper is only required in trace amounts by the body, and too much copper buildup could theoretically cause nausea, abdominal pain, tiredness, liver damage, and neurological effects
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The study identified key residues and structural features, such as the conformation of extracellular loop 1 (ECL1) in GIPR, that contribute to the differential binding and activation of the receptors
doi: 10.3945/jn.109.111526 42 BaggioLLDruckerDJ
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