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Osteoporosis was induced in female rats by ovariectomy, and the ovariectomized rats were treated with alendronate as standard treatment with a dose of 3 mg/kg orally and semaglutide with two doses (150 mcg/kg and 300 mcg/kg) S.C
10.2174/1381612824666180712110447 58 SeverA
Retatrutide's triple receptor activity produces larger total weight reduction in clinical trials (~24-29% vs ~20-22% for tirzepatide), but the side effect profile is more demanding during titration
Next expected milestone Planned regulatory submission window Lillys stated Q1 2027 filing window opensJanuary 1, 2027 This tracks a stated filing window, not an FDA approval date
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