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Your provider may slow the escalation if side effects are still present at the four-week mark
But because these effects are dose-dependent, clinical trial data has consistently shown that the frequency and severity of GI side effects are significantly higher at the maximum therapeutic doses compared to the lower, initial titration doses
doi:10.1152/ajpregu.00449.2010 174
They bypass strict approval processes that require extensive clinical trials to demonstrate safety, efficacy, and consistent quality
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