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What Each Compound Does Retatrutide (LY3437943) is a triple agonist: GLP-1 (cuts appetite, slows the stomach), GIP (improves insulin signaling), and glucagon (raises energy use and fat burning)
They recruited adult participants with and without a PAM variant known as p.S539W, had them drink a sugary solution and measured their blood every five minutes for the next four hours
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doi: 10.1007/s00018-020-03536-5 27 BackertSNeddermannMMaubachGNaumannM
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