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High-dose antioxidant supplements (vitamins C and E in megadoses) lack evidence for benefit in diabetes management and may interfere with certain laboratory tests or medications

Following your healthcare provider's schedule is key

In many cases, this has been due to issues with study design, such as: small sample sizes short follow-up durations differences in PRP preparation, administration, and dosages between studies large differences in the time between individual PRP treatments between studies inclusion of data from studies other than randomized controlled trials (RCTs) potential experimenter bias, or lack of blinding However, researchers continue to study PRPs effectiveness using high quality, large-scale RCTs

3.3 Changes in serum cobalamin by supplementation route and dosage Across 35 comparisons, the mean percentage increase in serum cobalamin following supplementation was approximately 293%, confirming the overall effectiveness of vitamin B12 interventions (Supplementary Table S4)