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The hippocampus shows reduced functional connectivity bilaterally to widespread regions, including the fusiform gyrus, frontal gyrus, temporal gyrus, anterior and posterior cingulate gyri, medial frontal gyrus, precuneus, and inferior parietal lobule, compared to healthy controls [105]
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The pivotal STEP-1 trial reported approximately 14.9 percent mean body weight loss at 68 weeks on semaglutide
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