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The rising prevalence of diabetes and obesity, combined with the proven efficacy and safety of GLP-1 receptor agonists, has fueled substantial market growth
Post-marketing surveillance has included reports of: Irritability Mood changes Emotional flattening Anxiety However: These reports are uncommon They do not prove causation They often involve other contributing factors After reviewing these reports, both the FDA and European Medicines Agency concluded there is no clear causal linkbetween GLP-1 medications and serious mood or behavioral disorders, but they recommend clinical monitoring, especially in patients with a psychiatric history
Abrupt discontinuation may reverse appetite control benefits
Liu YK, Ling S, Lui LMW, Ceban F, Vinberg M, Kessing LV, et al
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