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They produce metabolites, particularly short-chain fatty acids like butyrate, that regulate immune activity, maintain the integrity of the gut lining, and influence the immune behavior in tissues far from the gut itself

Additionally, the lower risk of blood vessel puncture and fewer nerve endings in the subcutaneous tissue in these areas make it a safe and effective option for peptide therapy [2]

In particular, AR signaling influences the fates of citrate that uniquely characterizes normal and malignant prostatic metabolism (i.e., mitochondrial export and extracellular secretion in normal prostate, mitochondrial retention and oxidation to support oxidative phenotype of primary PCa, and extra-mitochondrial interconversion into acetyl-CoA for fatty acid synthesis and epigenetics in the advanced PCa)

May 2007