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According to the United States Food and Drug Administration (FDA), dietary supplements are not monitored for safety or efficacy before hitting the market [6]

Avoid complete immobilization unless specifically indicated

Conditions like pernicious anaemia (an autoimmune condition affecting a protein called intrinsic factor vital for B12 absorption), stomach issues (such as from reduced stomach acid or certain medications like proton pump inhibitors), intestinal disorders (like Crohns disease or coeliac disease), or even surgical removal of parts of the small intestine (e.g., gastric bypass surgery) can prevent proper absorption

The rest rely on preclinical data alone