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In skeletally mature female rats, moderate energy restriction over 12 weeks had minimal negative effects on bone, but severe restriction significantly reduced bone mass and levels of IGF-1, leptin, and estradiol
Hitting a weight loss plateau is frustrating
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In a Phase 1b trial conducted in China, participants receiving the highest dose of UBT251 demonstrated an average weight loss of 15.1% over 12 weeks, while the placebo group gained 1.5%
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