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In both patient populations with pre-existing cardiovascular disease, DPP-4 inhibitors are recommended as one possible third-line therapy besides SGLT-2 inhibitors, thiazolidinediones, or insulin, when therapeutic goals are not met with the previous dual combination

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Clinical trials are now exploring CDK4/6 inhibitors, EZH2 inhibitors, and immune checkpoint inhibitors in genetically defined subgroups, with early data suggesting potential synergy in tumors with specific epigenetic signatures (Reuss et al., 2020

These differentially expressed genes are likely to be potential targets of caffeine and EGCG in mice with NASH