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Understanding the Study Timeline: Phase 2a vs Phase 3 Phase 2a MASLD Substudy (2023) - SOURCE OF 86% RESOLUTION DATA Status: COMPLETED and published Study Design: Part of larger Phase 2 obesity trial (NEJM 2023) Focused substudy on patients with MASLD Liver fat measured by MRI-PDFF (gold standard) Duration: 48 weeks Published results available This is where the 82.4% liver fat reduction and 86% resolution rate data comes from

F.et al (2007)

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4 Obesity is one of the strongest modifiable risk factors for AF