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In this study, we took an unbiased approach to unveil molecular partners working in concert with the GLP-1R to control -cell function, finding not only that the receptor engages with ER-endosome MCSs to organise its signalling, but that the main constituents of these inter-organelle contacts, namely the VAPs, are by a considerable margin the most prominent intracellular binding partners of active GLP-1R
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