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In tests of in vitro neurotrophic activity, Dihexa was observed to have a strong affinity for cellular pathways, which in the research context compares to the action of brain-derived neurotrophic factor (BDNF)
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In the TRIUMPH-1 Phase 3 trial, participants on the maximum dose of retatrutide (12 mg) lost an average of 28.3% of their body weight after 80 weeks, and up to 30.3% after 104 weeks in the study extension
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