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LKB1, a tumor suppressor, is a major mammalian AMPK kinase in the liver that activates AMPK by phosphorylating the Thr172 residues of AMPK subunits
The SURPASS-3 MRI substudy added another layer, showing tirzepatide actually reduced muscle fat infiltration across all doses, indicating improved muscle quality even as total muscle volume decreased
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10.1016/j.freeradbiomed.2007.11.004 69 MaX.-Y.ZhangM.FangG.ChengC.-J.WangM.-K.HanY.-M.et al (2021)
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