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Among the variations in the methods of administration: In most of the studies analyzed, only one infiltration was performed [17, 22, 25, 26, 30, 31], two RCT studies and one prospective study, on the other hand, compared patients who received a single dose of PRP with those who received two with some contrasting results
Most protocols begin with 1-2 injections weekly for 4-8 weeks
AT1R expression in mesangial cells and podocytes, induced by high glucose levels, promotes intracellular expression of profibrotic and pro-inflammatory mediators, such as transforming-growth factor beta (TGF- ), vascular endothelial growth factor (VGEF), and interleukin-6 (IL-6) leading to hyperplasia and hypertrophy, mainly of the proximal tubule, together with extracellular matrix production (34)
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