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In general, class I GRXs are enzymatically active as oxidoreductases on small disulfide model substrates like HED or Cys-SG, which functionally discriminates them from class II GRXs 14,15
24 Similarly, the AngioSafe Type 2 Diabetes study, in a case-control analysis of 3,154 patients with type 2 diabetes, found that GLP-1RA use was not associated with severe DR, although HbA 1c among other covariates such as diabetes durationwas
42:51-55 (2004) Engel SR, Dietrich FS, Fisk DG, Binkley G, Balakrishnan R, Costanzo MC, Dwight SS, Hitz BC, Karra K, Nash RS, Weng S, Wong ED, Lloyd P, Skrzypek MS, Miyasato SR, Simison M, Cherry JM
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