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3.5 Rapid Weight Loss and Lean Mass Reduction Weight loss during GLP-1 therapy includes: Adipose tissue Lean body mass Data from obesity trials indicate that without resistance training and adequate protein intake, a meaningful proportion of weight lost may be lean mass. Reduced protein intake may indirectly influence: Iron intake Zinc intake B12 intake This creates a secondary nutrient risk pathway unrelated to absorption but related to dietary composition

Consequently, effective management of patients with MASLD has become a critical clinical challenge

Neither benefits from splitting doses