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However, data to the contrary also exist and some small studies raised concerns that GLP1-RA use in CKD may be associated with more gastrointestinal side effects, hypoglycemic events, and loss of muscle mass 17,18

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Any major weight loss can include both fat and lean mass

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Both methylmalonic acid semialdehydes are converted to propionyl-CoA via the actions of aldehyde dehydrogenase 6 family member A1 (encoded by the ALDH6A1 gene)

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SGLT-2 inhibitors take a different route

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