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The phase III REDEFINE 1 study results, released in December 2024, showed that the CagriSema treatment group lost 22.7% of their weight after 68 weeks, significantly outperforming the single-target control drugs (semaglutide group lost 16.1%, cagrilintide group lost 11.8%)
doi: 10.1021/ja9018572 118 SandalioLMRomero-PuertasMC
If there is still no response after increasing the dose, pituitary reserve may be insufficient for secretagogue therapy, and direct GH replacement warrants evaluation
Increased rate of gluconeogenesis in type II diabetes mellitus
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