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Among them, dimethyl biguanide (known as metformin) was selected for clinical development with the suggestive name of Glucophage, which means glucose eater. The other biguanides, phenformin and buformin, were more potent than metformin, however in the late 1970s they were removed in most countries because of their association with lactic acidosis (Kathuria et al., 2021)
Gionchetti P, Rizzello F, Venturi A, Brigidi P, Matteuzzi D, Bazzocchi G, Poggioli G, Miglioli M, Campieri M: Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: a double-blind, placebo-controlled trial
They're not meant for long-term use without medical supervision, but they're very effective for the first 23 months on GLP-1
