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A 2024 study in monkeys found metformin reversed molecular aging markers (e.g., reduced inflammation, improved DNA repair) in multiple organs, effectively making their tissues 6 years younger. Lifespan : The evidence is mixed: In mice, metformin extended lifespan by 14% when started young, but had minimal effects in older mice, a 2013 study found

Because of this, ongoing constipation might be accepted as just part of the process, while stomach pain turns into something people just tolerate instead of talking about

IGF-1 is the downstream effector produced primarily by the liver in response to GH