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Preclinical work also suggests amylin signalling interacts with mesolimbic dopaminergic pathways implicated in the hedonic, reward-driven component of eating a mechanism explored further in our overview of how cagrilintide influences brain satiety circuits and reward-driven eating
doi: 10.1523/JNEUROSCI.3588-08.2008 142 MohammadiM.NasehiM.ZarrindastM
Pruritis and erythema at injection site may occur
Jeffrey Singer of the Cato Institute also proposed that making these drugs available without a prescription might reduce cost, increase access, and decrease stigma, but this change would likely take many years and receive pushback from clinicians
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