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Limitations include relatively short treatment periods (6 weeks per arm), potential carryover effects despite washout, modest sample size limiting power for subgroup analyses and exclusion of newer agents (e.g., tapentadol) and long-term safety outcomes, which may restrict applicability to broader clinical practice

State Coverage Overview Providers who treat Medicaid patients should verify their specific state's current formulary, as coverage policies are changing rapidly

Through these combined hormonal actions, ZepBound restores metabolic signaling patterns that are often disrupted in individuals with obesity or insulin resistance

The safety of tirzepatide during breastfeeding has not been well studied in humans, and there is currently no data on whether tirzepatide is excreted in human breast milk