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Because IV delivery bypasses digestion, levels rise quickly and your body decides what to do next
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A phase I trial (NCT02415621) evaluating adaptive dosing of abiraterone in metastatic castration-resistant prostate cancer demonstrated that intermittent androgen pathway suppression based on PSA dynamics could delay resistance and reduce cumulative toxicity
It is interesting to note that the peptide bond is not required for substrate binding specificity of PepT1 transporter (Brandsch et al
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