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The Science of Growth Hormone Decline Human growth hormone production peaks during adolescence and young adulthood, then progressively declines at an estimated rate of 14% per decade (1)
Phase 3 data shows Retatrutide producing 28.7% loss at 68 weeks compared to Tirzepatides 20.9% at 72 weeks
However, in states of leptin resistance such as obesity, this regulatory mechanism may be impaired (102, 103)
Retatrutide is a triple receptor agonist targeting GLP-1, GIP, and glucagon receptors a mechanism distinct from semaglutide and tirzepatide
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