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When these isolated senescence cells were presented with FOXO4-DRI peptide, researchers reported that the peptide appeared to block FOXO4 proteins, allowing p53 to bind with DNA, which led to the nuclear exclusion of p53 and induction of apoptosis of the senescent Leydig cells
These GLP-1s were injected right into the body, forgoing the digestive tract
Early trial results have been promising, fueling significant interest among both patients and healthcare providers
doi: 10.1016/j.pcad.2016.05.002 123
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