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At present, the main GLP-1RAs drugs that have been marketed include liraglutide, exenatide, albiglutide and dulaglutide ( The Effect of Glucagon-Like Peptide-1 Receptor Agonists on Osteoporosis Effects of Glucagon-Like Peptide-1 Receptor Agonists on Diabetic Osteoporosis Most patients with T2DM have normal bone density, but the risk of fracture is increased

However, they could be attributable to the GIP component of TZP that exerts some extra glycemic synergistic effects with GLP-1RA and some others over GLP-1RA

It also makes it harder for endothelial cells to absorb circulating amino acids

Because it is not clear that GLP-1 drugs are safe to take during pregnancy, women should stop these medications at least 2 months before trying to become pregnant or notify their doctor immediately if they become pregnant while taking these medications