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GLP-1 and GLP-2 are real gut peptides
In cohort studies, combination therapy was associated with a lower risk of MACE (RR 0.56 [95% CI 0.43, 0.71] and the kidney composite endpoint (RR 0.48 [95% CI 0.32, 0.73] relative to SGLT2 inhibitor or GLP-1 RA monotherapy
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Of note, glomerular hyperfiltration could be exacerbated by other hormonal changes associated with scarce glucose control, such as high glucagon levels [49, 51]
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