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In order to determine whether the genes found to be altered in the immortalized hypothalamic cell line were also expressed in the LH in vivo and altered by ingestion of fat, chow or sucrose, rats were exposed to respective diets for 1 h per day for 1 week on an every other day schedule

[1] The mechanisms of action are distinct: Ozempic works systemically through GLP-1 receptors to influence hormone secretion and gastric motility, whilst digestive enzymes act locally within the gastrointestinal lumen to catalyse nutrient breakdown

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