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After 56 weeks: Placebo group lost 1.2% of body weight Recommended dose (7.5/46 mg) group lost 7.8% of body weight Top dose (15/92 mg) group lost 9.8% of body weight The EQUIP trial enrolled 1,267 adults with class II and III obesity (BMI 35+)
Dhillon, S., & Semaglutide (2018)
pubmed.ncbi.nlm.nih.gov/18678604 Vaz FM, Melegh B, Bene J, Cuebas D, Gage DA, Bootsma A, Vreken P, van Gennip AH, Bieber LL, Wanders RJA
Why the gap exists Tirzepatide's added GIP receptor activity is thought to enhance insulin sensitivity and fat metabolism beyond what GLP-1 activation alone achieves
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