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Prevalence: Around 56% of people on semaglutide experience fatigue, ranging from mild tiredness to more persistent exhaustion

In October 2024, for instance, a real-world study in patients with type 2 diabetes linked semaglutide to a 40% to 70% drop in being diagnosed with Alzheimers

Preclinical studies have also revealed that dual agonists of GLP-1R and glucose-dependent insulinotropic polypeptide receptor (GIPR) have synergistic anti-inflammatory and neuroprotective effects, suggesting the potential advantages of multitargeting strategies (Yuan et al., 2024)