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Patients with pancreatitis history should have baseline pancreatic enzyme levels (amylase, lipase) drawn before starting medication and periodically during treatment, especially if abdominal pain, nausea, or digestive changes emerge
If GLP-1GIPLani depends on both incretin receptors for delivery, both loci will likely modulate response
But a Military Health System report published in January 2024 found that the number of active-duty service members who were prescribed a weight loss drug from January 2018 through June 2023 increased nearly a hundredfold, from 1.2 to 104.4 per 100,000 service members
This is particularly important for oral contraceptives, where the MHRA advises using a non-oral contraceptive method or adding a barrier method for 4 weeks after initiating tirzepatide and for 4 weeks after each dose increase
