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3.2 Absorption, Distribution, Metabolism and Excretion Studies in healthy subjects and in patients with type 2 diabetes have demonstrated that the pharmacokinetic properties of liraglutide make it suitable for once-daily dosing
While early rodent studies suggested alternating hypothalamic GHRH and somatostatin burst as primary drivers of GH pulsatility, other data implicated somatostatin as the key regulator of secretory timing and amplitude, with tonic GHRH secretion [16,17,18,19]
provides directionality and relative risks)
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