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All mice were approved by the Laboratory Animal Welfare Ethics committee at Harbin Institute of Technology (Approval No: IACUC- 2024138) and conducted in accordance with the Guide for Care and Use of Laboratory Animals and the institutional ethical guidelines for animal experiments
Instead of efficient aerobic energy production, the cells are forced into an inefficient anaerobic state, producing excess lactate
Elkind-Hirsch KE, et al
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Grx2 has close to 34% homology to Grx1 and was recently identified as the enzyme required for deglutathionylation reactions in mitochondria (Gladyshev et al., 2001
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