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Hyperuricemia can downregulate the expression of cell cycle proteins including D1, p-Rb, Ki67, and CDK4, inducing cellular senescence and consequently diminishing EGF/EGFR signaling
S.GuX.et al (2019)
Pattern of intra-family hetero-oligomerization involving the G-protein-coupled secretin receptor
By 2030, it is expected that this number could grow to more than 1 billion people, with over 120 million of those in the U.S
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