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Because of the way it works, it's only FDA-approved for people with certain genetic conditions, namely: Proopiomelanocortin (POMC) deficiency, Proprotein convertase subtilisin/kexin type 1 (PCSK1) deficiency, Leptin receptor (LEPR) deficiency, and Bardet-Biedl syndrome (BBS)
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The science underpinning today's biggest commercial launches often starts far from the companies that bring them to market, and the chain of talent involved stretches across discovery, development, regulatory, and beyond, a reminder of just how many people it takes to get a pill to market
Estrogen receptors in these same brain regions modulate GLP-1 receptor sensitivity
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